Professional scientists constantly develop new tools and epistemologies, because these resources offload cognitive operations that distract them from inquiry and discovery. Modern science and engineering rapidly evolve, but school content is still he same it was 50 years ago–we do not have good mechanisms to keep school content synchronized with professional science and engineering. National curricula are updated every few decades or so, while real science completely transforms itself every 5 or 10 years, and new fields of knowledge appear every other year. Paulo Blikstein’s research program contributes to the bridging effort by creating, empirically validating, and developing theory for new types of STEM education learning environments, content, and curricula. His research agenda focuses on four strands: low-cost technological infrastructure and tools, multimodal learning analytics, student-centered, emancipatory pedagogies, and epistemology.